A1784 | CAS:54-62-6 | Aminopterin | 氨基蝶呤

A1784  Aminopterin Sigma      ~98% (TLC), powder 窗体底端 货号 号 您的价格 RMB A1784-50MG 2,723.76 A1784-100MG 4,316.13 A1784-1G 21,675.42 Synonym: 4-Amino-PGA, 4-Aminofolic acid, 4-Aminopteroyl-L-glutamic acid CAS Number: 54-62-6 Empirical Formula (Hill Notation): C19H20N8O5 Molecular Weight: 440.41 Beilstein Registry Number: 69045 EC Number: 200-209-9 MDL number: MFCD00036692 PubChem Substance ID: 24278186 Description Linkage More potent, but more toxic, than methotrexate. Biochem/physiol Actions Folic acid antagonist. Aminopterin is actively transported into cells by the folate transporter. In the cell, it is converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase that, in turn, binds to dihydrofolate reductase and inhibits its activity. Aminopterin-polyglutamate is degraded intracellularly by γ-glutamyl hydrolase. 性质 assay ~98% (TLC) form powder color yellow solubility 2 M NaOH: soluble50 mg/mL (Solutions may be stored for 1-2 days at 4°C.)   DMSO: soluble (Solutions may be stored for 1-2 days at 4°C.) abs. ε1M/261 nm, 0.1 M NaOH 25,700   ε1M/282 nm, 0.1 M NaOH 24,500   ε1M/373 nm, 0.1 M NaOH 8,100 storage temp. −20°C Gene Information Research your gene in Your Favorite Gene powered by Ingenuity human ... FPGS(2356) mouse ... Fpgs(14287) 安全性 Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Hazard Codes T+ Risk Statements 61-28 Safety Statements 53-28-36/37-45 RIDADR UN2811 6.1/PG 1 WGK Germany 3 RTECS MA1050000