P5318 | CAS:26305-03-3 | Pepstatin A | 胃蛋白酶抑制剂

P5318  Pepstatin A Sigma      microbial 窗体底端 货号 号 目录价 RMB P5318-5MG 432.90 P5318-25MG 1,351.35 CAS Number: 26305-03-3 Empirical Formula (Hill Notation): C34H63N5O9 Molecular Weight: 685.89 Beilstein Registry Number: 2201362 EC Number: 247-600-0 MDL number: MFCD00060740 PubChem Substance ID: 24898620 Description Preparation Note Pepstatin can be dissolved at 1 mg/ml in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid). The inclusion of acetic acid may be necessary to dissolve this peptide in methanol or DMSO. It has been dissolved at 1 to 2 mg/ml in ethanol, but heat may be required for complete dissolution. Solutions of Pepstatin A can be heated as high as 60 °C without any decomposition of the peptide. Stock solutions at 1 mg/ml are stable at least a week at 4 °C. A 1 mM solution in methanol or DMSO is stable for months at -20 °C. If solutions become darker yellow, the reagent is hydrolyzing. A working concentration of 1 μM is stable for at least one day at room temperature. Biochem/physiol Actions Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources. 性质 biological source microbial mp 233 °C (dec.)(lit.) solubility 10% acetic acid in methanol: soluble1 mg/mL   ethanol: soluble1-2 mg/mL (with heat up to 60 °C)   : soluble storage temp. 2-8°C 安全性 Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter Safety Statements 22-24/25 WGK Germany 2 RTECS SC6155000